Murray has to work to book meeting with familiar foe Del Potro

Tennis- ATP- Rome Open- Novak Djokovic of Serbia v Juan Martin del Potro of Argentina

Tied at a set apiece and 1-all in the third after an hour-and-a-half of play, Almagro stood motionless, bent over in obvious distress, as a del Potro serve whizzed by.

Murray holds a 6-3 edge over the giant Argentine, notably downing Del Potro in a gruelling Olympic final to claim a second straight singles gold medal in Rio.

"I feel like each week I'm playing better and better tennis", said Anderson, who didn't start his year until February due to various injuries.

PARIS (AP) - Juan Martin del Potro quickly went from fierce competitor to friendly consoler at the French Open, showing deep reserves of compassion for an opponent who had to stop playing their second-round match because of a knee injury.

Murray toiled against the talented, inconsistent Martin Klizan, prevailing 6-7 (3-7) 6-2 6-2 7-6 (7-3) - rallying from a 5-2 deficit in the fourth set. They were locked at 1-1in the third when Almagro quit.

But, assuming he is close to fully fit, Del Potro will present a serious test of Murray's Roland Garros ambitions with the pair having played in two classic matches past year - the Rio Olympic final and a marathon Davis Cup five-setter - both stand-out memories.

He will next play former US Open champion Del Potro in a mouth-watering clash for a place in the last 16.

The 50th-ranked Slovakian has also failed to set the world alight on the red dirt this season, though he did run Novak Djokovic close on the hard courts of Acapulco in February.

A knee problem suffered in Rome earlier this month left him with no option but to retire and, for a player whose career has been beset by injuries in recent years, it was a bitter blow.

Controversial Australian 18th seed Nick Kyrgios is also out after he was beaten 5-7 6-4 6-1 6-2 by South African Kevin Anderson.

Del Potro said: "I felt something in my groin in the middle of the first set". I can imagine how you feel.

"I said to him, Try to be calm".

"I tried to play a solid match". And sometimes the heart is first, more than the tennis match or the tennis life.

This is the second time Edmund has made the last 32 at a slam.

Unseeded 21-year-old Karen Khachanov of Russian Federation continued his impressive debut, beating Czech 13th seed Tomas Berdych, a semifinalist seven years ago, 7-5, 6-4, 6-4. "I was sad, as well", said Del Potro, seeded 29th in Paris.

"Getting frustrated on the court is something that I have always battled with and always fought, probably since I was 20, 21 years old, and it's more venting", he explained.

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